Brand Name Lomotil Common Name diphenoxylate - atropine
The content of this page:
How does this medication work? What will it do for me?
Diphenoxylate - atropine is used to treat diarrhea that is not caused by infection with bacteria. This medication works by slowing down the movement of the bowels.
How should I use this medication?
The usual initial adult dose of diphenoxylate - atropine is 5 mg (2 tablets) 3 or 4 times daily to a maximum of 20 mg (8 tablets) taken in 24 hours. The children's dose is based on age and approximate body weight. This medication should not be used by children under 4 years old. As soon as symptoms are brought under control, reduce the dose or stop taking the medication as directed by your doctor.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
What form(s) does this medication come in?
Each round, white tablet, with "SEARLE" debossed on one side and "61" on the other side, contains diphenoxylate HCl 2.5 mg and atropine sulfate 0.025 mg. Nonmedicinal ingredients: acacia, cornstarch, magnesium stearate, mineral oil, sorbitol, sucrose, and talc.
Who should NOT take this medication?
Do not take diphenoxylate - atropine if you:
- are allergic to diphenoxylate, atropine, or any ingredients of the medication
- are being treated for diarrhea associated with pseudomembranous enterocolitis (diarrhea caused by antibiotic treatment) or for diarrhea caused by enterotoxin-producing bacteria
- have jaundice (a liver condition causing yellowing of skin and eyes)
Do not give this medication to children under 4 years of age.
What side effects are possible with this medication?
- abdominal cramps
- dizziness or lightheadedness
- dry skin or mouth
- general feeling of being unwell
- increased body temperature
- loss of appetite
- trouble sleeping
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- bloating (for people without ulcerative colitis)
- blurred vision or changes in near vision
- difficulty urinating
- fast heartbeat
- numbness in the hands or feet
- signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
- signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- skin rash or itching
- unusual excitement, nervousness, restlessness, or irritability
Stop taking the medication and seek immediate medical attention if any of the following occur:
- bloating (for people with ulcerative colitis)
- loss of consciousness/fainting
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
- signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
Are there any other precautions or warnings for this medication?
Dependence: Physical dependence, psychological dependence, and abuse are possible at high doses. Do not take more of this medication than your doctor has prescribed. People with a history of past or current substance use problems may be at greater risk of developing abuse or addiction while taking this medication.
Drowsiness/reduced alertness: This medication may cause drowsiness or dizziness. Avoid activities that require mental alertness, such as driving or operating dangerous machinery until you know how this medication affects you.
Liver function: This medication can cause complications in people with decreased liver function. If you have liver disease such as cirrhosis, hepatitis, or decreased liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Ulcerative colitis: If you have active ulcerative colitis, this medication may cause a severe complication called toxic megacolon. If you experience sudden, rapid abdominal distension (bloating), or if you have any other symptoms that worry you, contact your doctor immediately. Toxic megacolon is a medical emergency and must be treated quickly.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children less than 4 years of age.
What other drugs could interact with this medication?
There may be an interaction between diphenoxylate - atropine and any of the following:
- acetylcholinesterase inhibitors (e.g., donepezil, galantamine, rivastigmine)
- antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
- benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
- botulinum toxin
- chloral hydrate
- general anesthetics (medications used to put people to sleep before surgery)
- magnesium sulphate
- muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)
- narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
- potassium chloride (solid oral forms such as tablets)
- seizure medications (e.g., carbamazepine, clobazam, felbamate, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
- thiazide diuretics (water pills; e.g., hydrochlorothiazide, indapamide, metolazone)
- tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, imipramine)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
All material copyright MediResource Inc. 1996 – 2018. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Lomotil