Brand Name Naloxone Hydrochloride Injection by Sandoz Common Name naloxone
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How does this medication work? What will it do for me?
Naloxone belongs to the class of medications called opiate antagonists. It is used to reverse or prevent the effects of too much narcotic medication (codeine, fentanyl, morphine, oxycodone) having been taken. It works by blocking the activity of the narcotic medication, reversing the effects of the narcotic that may be life threatening. Signs of a narcotic overdose include trouble breathing, extreme drowsiness, pale and clammy skin, slow or no heartbeat, difficulty waking up, or unconsciousness.
Depending on how it is given, naloxone may begin to work as quickly as 1 to 5 minutes after it has been given.
How should I use this medication?
Before injecting this medication, emergency medical assistance should be requested by calling 9-1-1. This medication should not be used as a substitute for professional medical care.
Naloxone may be given by intravenous injection (into a vein), intramuscular injection (into a muscle), or subcutaneous injection (under the skin). The intravenous route is only recommended in emergency situations when a health care professional is present. The intramuscular route is recommended for use by caregivers or bystanders. Intramuscular injections may be given into the outer arm, upper thigh, or upper part of the buttocks.
The usual starting dose of naloxone is 0.4 mg. This dose may be repeated every 2 to 3 minutes as needed until the desired degree of reversal of symptoms is achieved. The protective effects of naloxone last for 30 to 90 minutes.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
What form(s) does this medication come in?
Each mL of aqueous injectable solution contains 0.4 mg of naloxone hydrochloride. Nonmedicinal ingredients: sodium chloride 8.6 mg, methylparaben 1.8 mg, and propylparaben 0.2 mg (as preservatives), hydrochloric acid to adjust pH, and water for injection.
Each mL of aqueous injectable solution contains 1 mg of naloxone hydrochloride. Nonmedicinal ingredients: sodium chloride 8.35 mg, methylparaben 1.8 mg, and propylparaben 0.2 mg (as preservatives), hydrochloride acid to adjust pH, and water for injection.
0.4 mg/mL Preservative-free
Each mL of aqueous injectable solution contains 0.4 mg of naloxone hydrochloride. Nonmedicinal ingredients: sodium chloride 9 mg, hydrochloric acid to adjust pH, and water for injection.
Who should NOT take this medication?
Do not take this medication if you are allergic to naloxone or any ingredients of the medication.
What side effects are possible with this medication?
The following side effects have been reported by at least 1% of people taking this medication.
- Symptoms of opioid withdrawal:
- aggressive behaviour
- blood pressure changes
- fast or irregular heartbeat
- runny nose
Are there any other precautions or warnings for this medication?
Non-opioid overdoses: This medication does not reduce the effects of an overdose caused by other medications such as barbiturates, benzodiazepines, stimulants, alcohol, or other sedatives. Giving this medication to a person who is unconscious due to a non-opioid overdose is not likely to cause them more harm.
Opioid dependence: When given to a person who has been using opioids for a long time, naloxone may cause withdrawal symptoms similar to stopping the opioid suddenly. These symptoms can include body aches, diarrhea, nausea, nervousness, restlessness, runny nose, sneezing, goose bumps, shaking, shivering, nausea, stomach cramps, fast or irregular heart rate, fever, sweating, increased blood pressure, and possible seizures.
Recent surgery: This medication should be used with caution in someone who has had recent surgery. Side effects such as blood pressure changes, increased heart rate, irregular heartbeat, fluid build-up in the lungs and heart attack have been reported.
Pregnancy: The effects of naloxone on a developing baby are unknown. This medication should not be used during pregnancy unless the benefits outweigh the risks.
Breast-feeding: It is not known if naloxone passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
What other drugs could interact with this medication?
There may be an interaction between naloxone and any of the following:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2018. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Naloxone-Hydrochloride-Injection-by-Sandoz