Brand Name Pliaglis Common Name lidocaine - tetracaine
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How does this medication work? What will it do for me?
This is a combination medication that contains lidocaine and tetracaine. It belongs to the class of medications called topical anaesthetics. This medication is used to numb intact skin before certain dermatological (skin) procedures. It is used before laser therapies, such as hair removal, facial resurfacing, tattoo removal, or treatment of varicose veins. It may also be used before insertion of needles into veins.
How should I use this medication?
If the procedure is not very painful, lidocaine - tetracaine should be applied to the area to be treated for 20 to 30 minutes before. If the procedure is more painful, it should be applied for 60 minutes before. The amount of cream estimated to cover the affected area should be measured out of the tube. Use a flat-surfaced tool such a metal spatula or tongue depressor to spread the cream evenly and thinly over the area to be treated.
After waiting for the cream to dry and form a peel, remove the peel from the skin and dispose of the peel safely. Use gauze to wipe away any cream or peel that does not come off the skin easily. Dispose of the removed peel safely. There is enough medication remaining in the dried film to harm a child or pet. Wash your hands immediately after removing and disposing the peel. This medication will cause numbness to the applied area. It is important to protect this area from scratches and potential causes of burning or freezing until the numbness has stopped.
Although lidocaine - tetracaine is applied to the skin, enough medication can be absorbed to cause side effects. Do not apply this medication to open wounds, irritated skin, or mucous membranes (e.g., inside the mouth or nose). It should not be applied too close to the eyes or inside the ear.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to use this medication exactly as prescribed by your doctor. This medication should be applied only once before the procedure and the treatment area needs to fully heal before reapplying the cream.
Store this medication in the refrigerator and protect from freezing. Keep it out of the reach of children.
What form(s) does this medication come in?
Each gram of cream contains 70 mg of lidocaine (7%) and 70 mg of tetracaine (7%). Nonmedicinal ingredients: calcium hydrogen phosphate (anhydrous), methylparaben, paraffin (white, soft), polyvinyl alcohol, propylparaben, purified water, and sorbitan monopalmitate.
Who should NOT take this medication?
Do not use this medication if you:
- are allergic to lidocaine, tetracaine or any ingredients of the medication
- are allergic to PABA
- have methemoglobinemia
- are treating large areas of the body (more than 400 cm²)
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
- redness or discoloration where the cream was applied
- sore throat
- tingling in the arms and legs
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- swelling, including face and eyelids
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
Are there any other precautions or warnings for this medication?
Liver problems: Reduced liver function may cause this medication to build up in the body. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Methemoglobinemia: Methemoglobinemia is a potentially fatal condition where the red blood cells are not able to carry adequate oxygen throughout the body. Lidocaine can cause methemoglobinemia and make symptoms of methemglobinemia worse. People with glucose-6-phosphate dehydrogenase deficiency may be more likely to experience this complication of the use of lidocaine.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: Lidocaine passes into breast milk. It is not known if tetracaine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.Children: The safety and effectiveness of using this medication have not been established for children under the age of 18. The safety and effectiveness of this medication have not been established for use before or after vaccinations.
What other drugs could interact with this medication?
There may be an interaction between lidocaine - tetracaine and any of the following:
- abiraterone acetate
- “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
- beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- ethinyl estradiol
- grapefruit juice
- HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
- HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
- macrolide antibiotics (e.g., clarithromycin, erythromycin, telithromycin)
- peginterferon Alfa-2b
- quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
All material copyright MediResource Inc. 1996 – 2018. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Pliaglis