Brand Name Lorazepam Injections USP Common Name lorazepam
The content of this page:
How does this medication work? What will it do for me?
Lorazepam belongs to the class of medications called benzodiazepines. Lorazepam is used for the short-term relief of the symptoms of excessive anxiety. It works by slowing down the communication between the nerves in the brain (i.e., the central nervous system).
Some people experience some improvement in anxiety about half an hour after taking lorazepam. Injectable lorazepam can be used as an initial treatment for the control of prolonged seizures (status epilepticus).
How should I use this medication?
Anxiety: The recommended starting dose of lorazepam for adults is 2 mg per day. The dose is individualized according to your specific needs and response to the medication. This dose can be increased by your doctor to as high as 6 mg per day in 2 to 4 divided doses.
If you are taking the sublingual tablets, place the tablet under the tongue. The medication will dissolve in about 20 seconds. You should not swallow for at least 2 minutes to allow the medication to be absorbed into the body.
Seizures: The dose of injectable lorazepam for seizures is based on body weight and given by a trained health care provider in a hospital.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you have been taking this medication regularly, do not stop taking the medication without speaking with your doctor. A gradual reduction in dose is recommended when stopping this medication to avoid withdrawal effects.
If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store lorazepam tablets at room temperature, protect from light and moisture, and keep them out of the reach of children. The lorazepm injection is stored in the fridge.
What form(s) does this medication come in?
Each mL of sterile solution for injection contains lorazepam 4 mg. Nonmedicinal ingredients: benzyl alcohol, polyethylene glycol, and propylene glycol.
Who should NOT take this medication?
Do not take lorazepam if you:
- are allergic to lorazepam, other benzodiazepines, or any ingredients of the medication
- have acute narrow-angle glaucoma
- have myasthenia gravis
What side effects are possible with this medication?
- clumsiness or unsteadiness
- dizziness or lightheadedness
- slurred speech
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- abnormal thinking (disorientation, delusions, or loss of sense of reality)
- behavioural changes (e.g., aggressiveness, angry outburst)
- blurred vision or other changes in vision
- changes in appetite
- changes in sexual desire or ability
- dry mouth
- false sense of well-being
- fast, irregular heartbeat
- increased watering of mouth
- memory problems
- muscle spasm
- muscle weakness
- nausea or vomiting
- problems with urination
- unusual bleeding or bruising
- unusual excitement, nervousness, or irritability
- unusual tiredness or weakness
- yellow eyes or skin
Stop taking the medication and seek immediate medical attention if any of the following occur:
- breathing difficulties
- chest pain
- convulsions (seizures)
- skin rash or itching
- swelling of face, lips, tongue, or throat
- vision changes or drooping eyelid
Are there any other precautions or warnings for this medication?
HEALTH CANADA ADVISORY
December 22, 2017
Health Canada has issued new restrictions concerning the use of Ativan® (lorazepam). To read the full Health Canada Advisory, visit Health Canada's web site at healthycanadians.gc.ca.
Allergic reaction: Some people may develop a serious allergic reaction to this medication. Signs of an allergic reaction include a severe rash, hives, swollen face or throat, or difficulty breathing. If these occur, seek immediate medical attention.
Dependence and withdrawal: Physical dependence (a need to take regular doses to prevent physical symptoms) has been associated with benzodiazepines such as lorazepam. Severe withdrawal symptoms may be experienced if the dose is significantly reduced or suddenly discontinued. Withdrawal symptoms can include:
- abdominal cramps
- extreme anxiety
- memory impairment
- muscle pain
- sleep problems
Reducing the dose gradually under medical supervision can help prevent or decrease these withdrawal symptoms. If you have a history of addiction or substance use problems, discuss the risks and benefits of the medication with your doctor.
Depression: People who have preexisting depression may experience emerging or worsening symptoms of depression while taking this medication. If you experience this, contact your doctor as soon as possible. People with depression should be treated with appropriate antidepressant therapy.
Drowsiness/reduced alertness: People taking lorazepam should not drive a car or perform hazardous tasks until they determine that this medication does not impair their ability to perform these tasks safely. Avoid drinking alcohol, as it can increase the drowsiness effects of this medication.
Lung disease: If you have underlying lung disease (e.g., chronic obstructive pulmonary disease, sleep apnea), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: Taking lorazepam during the first trimester of pregnancy may result in an increased risk of certain birth defects. This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking lorazepam, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children and adolescents: The safety and effectiveness of using this medication have not been established for those under 18 years of age.
Seniors: Seniors may be more likely to experience side effects of lorazepam, such as sedation (drowsiness) and impaired coordination. Seniors should discuss with their doctor the risks and benefits of taking this medication.
What other drugs could interact with this medication?
There may be an interaction between lorazepam and any of the following:
- anticonvulsants (e.g., carbamazepine, phenytoin, valproic acid)
- antidepressants (e.g., fluoxetine, paroxetine, venlafaxine)
- antihistamines (e.g., chlorpheniramine, diphenhydramine)
- antipsychotics (e.g., olanzapine, risperidone)
- barbiturates (e.g., phenobarbital, secobarbital)
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- narcotics (e.g., codeine, morphine)
- other benzodiazepines (e.g., clonazepam, temazepam)
- sedatives (e.g., zolpidem, zopiclone)
- tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications; you should let your prescriber know if you use them.
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