Brand Name Apo-Valganciclovir Common Name valganciclovir
The content of this page:
How does this medication work? What will it do for me?
Valganciclovir belongs to a group of medications known as antivirals. It is used to treat a viral eye infection called cytomegalovirus (CMV) retinitis for people with acquired immunodeficiency syndrome (AIDS). It can also be used to prevent CMV disease in people who have received an organ transplant and are at risk of the condition. It works by slowing the growth of the CMV virus that causes the infection. Valganciclovir does not cure CMV disease, but it does prevent the virus from spreading as quickly as it would without treatment.
How should I use this medication?
For people with active CMV retinitis, the usual dose is 900 mg twice a day with food for 21 days. After 21 days of treatment, or for people with inactive CMV retinitis, the dose is 900 mg once a day with food.
For people who have received a solid organ transplant, the recommended dose is 900 mg once daily with food starting within 10 days of transplantation and continued for 100 days after the transplantation.
If you have reduced kidney function, you may require a lower dose of valganciclovir, as recommended by your doctor.
If you are using the tablets, do not break or crush them. If you are using the oral solution, use the measuring device provided for accurate dosing. Shake the bottle well for about 5 seconds before each use.
If you accidentally get broken tablets or solution on your skin, wash the area thoroughly with soap and water. If you accidentally get broken tablets or solution in your eyes, rinse your eyes thoroughly with sterile or plain water.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. The amount of virus in your blood may increase even if you stop your medication for a short time. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store the tablets at room temperature, protect them from moisture, and keep them out of the reach of children.
Store the oral solution in the refrigerator and keep it out of the reach of children. Discard any solution that is not used within 49 days.
What form(s) does this medication come in?
Each pink, oval-shaped, bevelled-edged, biconvex, film-coated tablet, engraved "APO" on one side and "VGC450" on the other side contains 496.3 mg of valganciclovir hydrochloride (corresponding to 450 mg valganciclovir). Nonmedicinal ingredients: crospovidone, microcrystalline cellulose, and stearic acid. Opadry pink film coating: FD&C Blue No. 2/indigo carmine aluminum lake, FD&C Red No. 40/allura red AC aluminum lake, FD&C Yellow No. 6/sunset yellow FCF aluminum lake, lecithin (soya), polyvinyl alcohol-part hydrolyzed, talc, titanium dioxide, and xanthan gum.
Who should NOT take this medication?
Valganciclovir should not be taken by anyone who:
- is allergic to valganciclovir, ganciclovir, or to any of the ingredients of the medication
- is allergic to acyclovir or valacyclovir
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention
Check with your doctor as soon as possible if any of the following side effects occur:
- numbness, tingling, or burning sensations
- signs of an infection (e.g., cough, chills, mouth sores, redness on any area of your body, nasal congestion, sore throat, runny nose, night sweats, pain or burning when urinating)
- signs of graft rejection (transplanted organ not functioning properly; e.g., feeling ill or uncomfortable, fever)
- signs of kidney problems (e.g., swelling of the legs, decreased urine amount, lower back pain)
- symptoms of anemia (e.g., feeling tired, shortness of breath, paleness, or a fast heartbeat)
- symptoms of depression (e.g., lack of motivation or energy, feelings of worthlessness or guilt, difficulty concentrating)
- unusual bleeding and bruising
- unusual tiredness or weakness
- white patches on the mouth, tongue, or throat
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., swelling of the face or throat, hives, or difficulty breathing)
Are there any other precautions or warnings for this medication?
Blood disorders: Valganciclovir can cause a reduction in certain blood cells, which can lead to serious problems. People with certain severe blood disorders (e.g., anemia, neutropenia, thrombocytopenia) may not be able to use this medication. Your doctor will monitor you closely while you are taking this medication for any signs of blood cell problems.
Drowsiness/reduced alertness: Valganciclovir may reduce alertness. Avoid activities such as driving or operating machinery until you know whether the medication affects you in this way.
Kidney disease: People with reduced kidney function may need a lower dose of this medication. Valganciclovir may also cause kidney problems. Your doctor will monitor you while you are on this medication.
Fertility and pregnancy: Valganciclovir may decrease fertility in both men and women, and these effects may last for some time after the medication has been stopped. This medication should not be used during pregnancy because it can harm the developing child. Men and women who are taking valganciclovir should ensure their partners are aware of the risks and practice effective birth control, which includes barrier protection (e.g., condoms) and one additional form of contraception (e.g., birth control pills, intrauterine device). Effective birth control should be practiced for at least 90 days after stopping the medication.
Breast-feeding: It is not known if valganciclovir passes into breast milk. It is recommended that women taking this medication should not breast-feed.
Children: The safety and effectiveness of using this medication have not been established for children.
What other drugs could interact with this medication?
There may be an interaction between valganciclovir and any of the following:
- amphotericin B
- imipenem - cilastatin
- mycophenolate mofetil
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2018. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Apo-Valganciclovir