Brand Name Irbesartan by Sanis Common Name irbesartan
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How does this medication work? What will it do for me?
Irbesartan belongs to a family of medicines known as angiotensin II receptor blockers. These medicines are used to lower high blood pressure and work by relaxing blood vessels. Irbesartan is used to lower blood pressure and decrease the rate of the progression of kidney damage in patients with type 2 diabetes.
Angiotensin II is a chemical that the body releases to cause the constriction of blood vessels. Irbesartan blocks the action of angiotensin II, resulting in the relaxation of the blood vessels. This relaxation causes the blood pressure to decrease. The full effects of irbesartan are usually seen within about 4 weeks. It can be used alone or in combination with thiazide diuretics (water pills; e.g., hydrochlorothiazide).
This medication does not cure blood pressure, but it does help to control it, when it is taken regularly. Do not stop taking this medication without discussing the risks and benefits with your doctor.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
How should I use this medication?
The usual starting dose of irbesartan is 150 mg daily at approximately the same time each day. If you are taking other medication to reduce your blood pressure, your doctor may start you with a dose of 75 mg daily. The doctor may decide to increase the dose to 300 mg once a day if your blood pressure has not come down enough.
Irbesartan may be taken with or without food but should be taken in the same manner each day.
Make sure you follow your doctor's instructions about monitoring your blood pressure to ensure that you receive the maximum benefit from the medication.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
What form(s) does this medication come in?
Each white-to-off-white, film-coated, capsule-shaped tablet, with one side of the tablet debossed with number "93" and the other side of the tablet debossed with number "7464" contains irbesartan 75 mg. Nonmedicinal ingredients: croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, poloxamer, polydextrose, polyethylene glycol, povidone, pregelatinized starch, silica, and titanium dioxide.
Each white-to-off-white, film-coated, capsule-shaped tablet, with one side of the tablet debossed with number "93" and the other side of the tablet debossed with number "7465" contains irbesartan 150 mg. Nonmedicinal ingredients: croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, poloxamer, polydextrose, polyethylene glycol, povidone, pregelatinized starch, silica, and titanium dioxide.
Each white-to-off-white, film-coated, capsule-shaped tablet, with one side of the tablet debossed with number "93" and the other side of the tablet debossed with number "7466" contains irbesartan 300 mg. Nonmedicinal ingredients: croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, poloxamer, polydextrose, polyethylene glycol, povidone, pregelatinized starch, silica, and titanium dioxide.
Who should NOT take this medication?
Do not take irbesartan if you:
- are allergic to irbesartan or any ingredients of the medication
- have experienced a serious allergic reaction to another angiotensin II receptor blocker (ARB) (e.g., candesartan, losartan, valsartan)
- have diabetes mellitus or severely reduced kidney function and are taking the medication aliskiren or an angiotensin-converting enzyme (ACE) inhibitor
- are pregnant
- are breast-feeding
- have galactose intolerance or glucose malabsorption (a rare hereditary disease)
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
- swelling of the ankles
- trouble sleeping
- unusual tiredness
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- dark brown urine
- dizziness rising from a sitting or lying position
- muscle pain, tenderness, or weakness
- ringing in the ears
- signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
- signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- signs of too much potassium in the blood (e.g., muscle weakness, irregular heartbeat, general feeling of being unwell)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
Are there any other precautions or warnings for this medication?
HEALTH CANADA ADVISORY
February 4, 2014
Health Canada has issued new restrictions concerning the use of irbesartan. To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Drowsiness/reduced alertness: Irbesartan, like other medications for blood pressure may cause dizziness and lightheadedness, especially if you have been taking a diuretic (water pill). This may affect your ability to drive or operate machinery. Avoid these and other activities until you have determined that this medication does not affect you in this way.
Heart disease: If you have a history of heart problems, such as a recent heart attack or stroke, narrowing of the heart valves (valvular stenosis) or other heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Kidney function: Irbesartan may affect the function of the kidneys, especially for people who already have kidney problems. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Low blood pressure: Occasionally, a larger-than-expected decrease in blood pressure occurs after taking irbesartan. In some cases, this happens after the first dose. It is more likely to occur if you take diuretics (water pills) or the medication aliskiren, have a reduced salt intake, are on dialysis, or are experiencing diarrhea or vomiting. Blood pressure should be monitored more often in these situations. If you have low blood pressure or are just starting to take this medication, move slowly from a reclining to an upright position to reduce the risk of dizziness.
Potassium levels: This medication may affect potassium levels in the blood, especially when used for heart failure, or when taken with other medications called ACE inhibitors or diuretics such as spironolactone. Your doctor will monitor your potassium levels while you are on this medication. Avoid using salt substitutes that contain potassium while you are taking irbesartan.
Pregnancy: Irbesartan can cause severe harm or death to a developing baby if it is taken by the mother during pregnancy. Therefore, this medication should not be taken by pregnant women. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if irbesartan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.Seniors: Older adults may be more likely to experience side effects of this medication.
What other drugs could interact with this medication?
There may be an interaction between irbesartan and any of the following:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
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