Brand Name Omeprazole by Sivem Common Name omeprazole
The content of this page:
How does this medication work? What will it do for me?
Omeprazole belongs to the family of medications called proton pump inhibitors (PPIs). It slows or prevents the production of acid within the stomach.
Omeprazole is used to treat conditions where reduction in acid secretion is required for proper healing, including stomach and intestinal ulcers (gastric and duodenal ulcers), the prevention and treatment of ulcers associated with medications known as NSAIDs, reflux esophagitis, Zollinger-Ellison syndrome, heartburn, and gastroesophageal reflux disease (GERD).
It is also used in combination with antibiotics to treat stomach ulcers caused by H. pylori bacteria.
How should I use this medication?
The usual recommended dose of omeprazole is 10 mg to 40 mg once daily. The dose and length of treatment depends on the condition being treated. This medication can be taken with or without food and should be swallowed whole with water.
When used to treat ulcers in the duodenum, the recommended adult dose is 20 mg taken once daily for 2 to 4 weeks.
To treat ulcers in the stomach, reflux esophagitis, and ulcers associated with the use of NSAIDs, the recommended adult dose is 20 mg taken once daily for 4 to 8 weeks.
For treatment of heartburn, the recommended adult dose is 20 mg daily.
When used to treat stomach ulcers caused by H. pylori in adults, the dose of omeprazole is 20 mg twice daily taken with amoxicillin 1,000 mg twice daily and clarithromycin 500 mg twice daily, all for 7 days. Another dosing regimen for H. pylori infections is omeprazole 20 mg, metronidazole 500 mg, and clarithromycin 250 mg, all twice daily for 7 days.
When treating Zollinger-Ellison syndrome, the dose of omeprazole varies, but is often higher than the doses used to treat ulcers. Doses larger than 80 mg daily are often needed.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 12 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.
What form(s) does this medication come in?
20 mg capsule
Each hard gelatin, two-piece capsule consisting of a dark pink cap imprinted with "OME 20" and a pink body imprinted with "OME 20", filled with pellets contains omeprazole 20 mg. Nonmedicinal ingredients: carrageenan, croscarmellose sodium, dibutyl sebacate, hypromellose, hypromellose phthalate, iron oxide red, lactose anhydrous, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, polysorbate 80, potassium chloride, povidone, talc, titanium dioxide, and water.
20 mg delayed-capsule
Each hard gelatin capsule with an opaque pink body and an opaque reddish-brown cap, imprinted "APO 020" contains omeprazole 20 mg. Nonmedicinal ingredients: mannitol, povidone, magnesium hydroxide, triethyl citrate and eudragit, gelatin, red iron oxide, and titanium dioxide.
Who should NOT take this medication?
Do not take this medication if you are allergic to omeprazole or any ingredients of the medication.
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
- abdominal or stomach pain
- diarrhea or loose stools
- dry mouth
- trouble sleeping
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- diarrhea (watery and severe; may also be bloody)
- increased sensitivity to sunlight
- joint pain
- mild skin rash or itching
- muscle aches or cramps
- pain or burning in the mouth or throat
- sensation of burning, prickling, or numbness
- signs of liver damage (yellow skin or eyes, dark urine, loss of appetite, abdominal pain, fever, and fatigue)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of an allergic reaction (e.g., difficulty breathing, hives, swelling of the face or throat)
- signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
- signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
Are there any other precautions or warnings for this medication?
Diarrhea: When gastric acid is decreased, the number of bacteria normally in the digestive system increases. Occasionally, this can cause serious infection in the digestive tract. If you experience watery, foul-smelling bowel movements after starting to take omeprazole, contact your doctor as soon as possible.
Fluid and electrolyte balance: Omeprazole, like other PPIs, may cause the levels of electrolytes such as potassium, sodium, magnesium, chloride, and calcium in the blood to change while taking this medication. If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; dry mouth; numb hands, feet, or lips; or racing heartbeat, contact your doctor as soon as possible. Your doctor will do blood tests regularly to monitor the levels of these electrolytes in your blood while you are taking this medication.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication. People with severe liver disease should generally not take more than 20 mg of omeprazole daily.
Methotrexate interaction: Omeprazole, like other medications in this group, may interact with methotrexate when the two medications are used at the same time. This combination may lead to higher than expected amounts of methotrexate in the body and can cause serious side effects, including kidney damage, irregular heartbeat, anemia, or infection. If you take omeprazole and are also going to receive a dose of methotrexate, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Osteoporosis-related fractures: Studies suggest that the use of omeprazole, like other PPIs may be related to an increase risk of fractures, particularly for people who take this medication for a year or longer. The lowest dose of this medication to control the symptoms, taken for the shortest period of time is less likely to cause these problems.
Severe stomach problems: If you have recurrent vomiting, difficulty swallowing, blood in the stool, coughing up of blood, or significant unintentional weight loss, check with your doctor immediately.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, call your doctor immediately.
Breast-feeding: It is not known if omeprazole passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
Seniors: Using the same dosage, seniors reach higher blood levels of omeprazole than younger people. Therefore, seniors may need to take reduced doses and should generally not take more than 20 mg of omeprazole daily.
What other drugs could interact with this medication?
There may be an interaction between omeprazole and any of the following:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
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