Who should NOT take this medication?
Do not take this medication if you:
- are allergic to naproxen, naproxen sodium, or any ingredients of the medication
- are in the third trimester (last 3 months) of pregnancy
- have a bleeding ulcer in the stomach or intestines
- have had asthma, an allergic reaction, or allergic-type reaction (e.g., nasal polyps; runny nose; sinus congestion; difficulty breathing; wheezing; itchy skin rash; swelling of the face, throat, or tongue) to ASA or any other nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen, ketorolac, indomethacin)
- have inflammatory bowel disease (e.g, ulcerative colitis, Crohn's disease)
- have severely reduced kidney function
- have severely reduced liver function or active liver disease
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- ringing or buzzing in the ears
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- asthma (e.g., wheezing, shortness or breath, chest tightness)
- swelling of the feet or lower legs
- vision changes
Stop taking the medication and seek immediate medical attention if any of the following occur:
- vomiting blood
- bloody or black tarry stools
- severe stomach pain
- symptoms of an allergic reaction (hives; itching; difficulty breathing; swelling of the face, mouth, tongue, or throat)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergic reactions: This medication should not be given to people who have had a reaction to acetylsalicylic acid (ASA) that included a runny nose, itchy skin rash, nasal polyps, or shortness of breath and wheezing. If you experience symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; wheezing; swelling of the face, tongue, or throat), get immediate medical attention. If you have a history of asthma, runny nose not caused by the common cold, or nasal polyps, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Blood clotting: This medication may reduce the ability of the blood to clot for some people. If you are taking blood thinners (e.g., warfarin), discuss with your doctor or pharmacist how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.
Drowsiness/reduced alertness: As with other NSAIDs, naproxen sodium can cause drowsiness, dizziness, blurred vision, and ringing in the ears. Avoid driving and other activities that require alertness and concentration until you determine how this medication affects you.
Heart failure and high blood pressure: NSAIDs such as naproxen sodium can cause fluid retention and edema (swelling). This can lead to high blood pressure or worsening of heart failure. If you have heart failure or high blood pressure, discuss with your doctor or pharmacist how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Ulcers or bleeding in the stomach or intestines: NSAIDs such as naproxen sodium can cause stomach ulcers and bleeding from the stomach. If you have a history of these conditions, discuss with your doctor or pharmacist how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. People with inflammatory bowel disease, such Crohn's disease or ulcerative colitis or those who have ulcers in the stomach or intestines that are bleeding, should not take this medication.
If you experience symptoms of bleeding in the digestive system, such as black, tarry stools or stomach pain, contact your doctor immediately.
Pregnancy: This medication should not be used during the third trimester (last 3 months) of pregnancy. This medication should not be used during the first and second trimester (first 6 months) of pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
This medication may reduce your ability to become pregnant. Taking this medication while trying to become pregnant is not recommended.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking naproxen sodium, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children under 12 years of age.
Seniors: Seniors appear to have a higher risk of side effects. If you are over the age of 65, use the lowest effective dosage under close medical supervision. Ask your doctor or pharmacist about all available treatment options that may be right for you.
What other drugs could interact with this medication?
There may be an interaction between naproxen sodium and any of the following:
- acetylsalicylic acid (ASA)
- aminoglycoside antibiotics (e.g., amikacin, gentamicin, tobramycin)
- angiotensin converting enzyme inhibitors (ACEIs; captopril, enalapril, ramipril)
- angiotensin receptor blockers (ARBs; e.g., candasartan, irbesartan, losartan)
- beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
- bisphosphonates (e.g., alendronate, etidronate)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- oral corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
- diuretics (e.g., spironolactone, triamterene, furosemide, hydrochlorothiazide)
- low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
- multivitamins with Vitamin A, D, E
- other NSAIDs (e.g., ketorolac, ibuprofen, diclofenac)
- omega-3 fatty acids
- quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
- serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
- sodium phosphates
- tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2018. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Aleve