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Medications Lexicon

How does this medication work? What will it do for me?

Metoprolol belongs to the class of medications called beta-blockers. Metoprolol is used to treat high blood pressure and prevent the symptoms of certain types of angina (chest pain). It is also used to help reduce the risk of death right after a heart attack. It works by reducing the demands put on the heart.

Metoprolol is also taken by people who have had a heart attack to reduce the risk of having another one. Metoprolol is often used in combination with other high blood pressure medications such as diuretics (water pills) when the use of one medication by itself is not enough to control blood pressure.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The usual maintenance dose of metoprolol ranges from 100 mg daily to 200 mg daily, however the dose may be increased to 400 mg daily if necessary to obtain symptom control. Immediate-release tablets are taken in 2 divided doses while slow-release tablets are taken once a day.

The medication should be taken with or soon after a meal. Try to take the doses of metoprolol at the same time each day.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

25 mg
Each white, round, biconvex, film-coated tablet, marked with "M" over "25" on one side and plain on the other, contains 25 mg of metoprolol. Nonmedicinal ingredients: colloidal silicon dioxide, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate, povidone, sodium starch glycolate, talc, polysorbate 80, and titanium dioxide.

50 mg
Each light pink, capsule-shaped, film-coated tablet, marked with "M|50" on one side and plain on the other, contains 50 mg of metoprolol. Nonmedicinal ingredients: colloidal silicon dioxide, D&C Red No. 30 Aluminum Lake, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate, povidone, sodium starch glycolate, talc, polysorbate 80, and titanium dioxide.

100 mg
Each light blue, capsule-shaped, film-coated tablet, marked with "M|100" on one side and plain on the other, contains 100 mg of metoprolol. Nonmedicinal ingredients: colloidal silicon dioxide, FD&C Blue No. 2 Aluminum Lake, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate, povidone, sodium starch glycolate, talc, polysorbate 80, and titanium dioxide.

Who should NOT take this medication?

Do not take metoprolol if you:

  • are allergic to metoprolol or any ingredients of the medication
  • are allergic to other beta blockers
  • are scheduled to have anesthesia with an agent that causes myocardial depression (e.g., ether)
  • have a condition known as right ventricular failure caused by excessive blood pressure in the lungs
  • have a condition known as "sick sinus syndrome"
  • have a slow heartbeat caused by heart rhythm problems
  • have asthma or other obstructive respiratory diseases (for the intravenous form of metoprolol only)
  • have an untreated pheochromocytoma (a tumour of the adrenal glands)
  • have cardiogenic shock
  • have overt heart failure
  • have serious heart block
  • have severe circulatory disorders
  • have had a heart attack accompanied by:
    • a heart rate less than 45 beats per minute
    • significant heart block
    • very low blood pressure
    • moderate to severe cardiac failure

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain or discomfort
  • changes in sexual desire or ability
  • constipation
  • diarrhea
  • dizziness or lightheadedness when rising from a sitting or lying position
  • dry mouth
  • fatigue
  • hair loss
  • headache
  • increased sensitivity to sunlight
  • increased sweating
  • nausea
  • trouble sleeping
  • unusual tiredness or weakness with activity
  • vivid dreams
  • vomiting
  • weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • back or joint pain
  • breathing difficulty or wheezing
  • changes in hearing
  • chest pain
  • cold hands and feet
  • confusion
  • flare-up of psoriasis (e.g., pinpoint-sized red spots on skin, red, scaling, or crusted skin)
  • hallucinations (hearing or seeing things that aren't there)
  • numbness or tingling sensation in the extremities
  • signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, difficulty breathing, tiredness with activity, swelling of feet, ankles, or lower legs)
  • signs of kidney problems (e.g., increased need to urinate, decreased urine production, skin itching, nausea, vomiting, rash)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • slow heartbeat (especially less than 40 beats per minute)
  • symptoms of low blood pressure (e.g., dizziness, fatigue)
  • vision changes (e.g., blurred vision, dry eyes, eye pain)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • fingers or toes cold to touch, painful or discoloured
  • symptoms of a serious allergic reaction (such as swelling of the face or throat, hives, or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Breathing conditions: In general, people who have asthma and certain other lung problems should avoid taking a beta-blocker such as metoprolol, as it can cause breathing difficulty. If you have breathing problems and your doctor prescribed metoprolol for you, it may be at a lower dose, and your doctor will monitor you regularly while you are taking this medication. If you have breathing problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Diabetes: The signs of low blood sugar may not be as noticeable when taking metoprolol. This medication may make it more difficult for people with diabetes to control their blood sugar. If you have diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor will monitor you while you are taking this medication and may need to adjust the doses of antidiabetes medications.

Dizziness or fainting: Dizziness or fainting are side effects of metoprolol and may occur after first starting this medication. Avoid driving and other potentially hazardous tasks until you have determined how this medication affects you.

Heart disease: Beta-blockers, such as metoprolol, can worsen existing heart failure. It is important to take metoprolol exactly as prescribed by your doctor to decrease the chance of this happening. If you have a history of heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Hyperthyroidism (high level of thyroid hormones): Metoprolol can mask the symptoms that occur when you have hyperthyroidism (high levels of thyroid hormones). If you have hyperthyroidism, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Stopping the medication suddenly could worsen this condition.

Kidney function: Kidney function may change as a result of taking metoprolol. Your doctor will monitor for this, and may adjust your dose if necessary. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience puffy hands, face or feet, high blood pressure, unusual muscle cramping, or darkened urine, this medication may be affecting how well your kidneys are working. If you notice any of these symptoms, contact your doctor as soon as possible.

Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Pheochromocytoma: This medication can worsen the symptoms of pheochromocytoma (a tumour of the adrenal gland) if it is taken alone. If you have a pheochromocytoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Severe allergies: If you have allergies severe enough to cause anaphylaxis (a severe allergic reaction where swelling of the face, lips, and throat make it difficult to breathe), discuss with your doctor about what to do if you have an allergic reaction. Metoprolol may make it more difficult to treat severe allergic reactions with epinephrine.

Stopping the medication: People with heart disease who stop taking this medication abruptly may experience severe effects, such as chest pain, irregular heartbeat, or heart attack. If you have heart disease, do not stop taking this medication without checking with your doctor first. When this medication needs to be stopped, it should be done gradually under supervision of your doctor.

Surgery: If you are scheduled for surgery, inform all health care professionals involved in your care that you are taking metoprolol.

Pregnancy: The medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking metoprolol, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Normal adult doses of metoprolol may cause a drop in blood pressure that is larger than anticipated. Lower doses may be necessary for seniors.

What other drugs could interact with this medication?

There may be an interaction between metoprolol and any of the following:

  • abiraterone acetate
  • acetylcholine
  • alcohol
  • aldesleukin
  • aliskiren
  • alpha agonists (e.g., clonidine, methyldopa)
  • alpha-1 blockers (e.g., doxazosin, prazosin, tamsulosin)
  • amiodarone
  • amifostine
  • amphetamines (e.g., dextroamphetamine, lisdexamphetamine)
  • anesthetic agents
  • angiotensin-converting enzyme inhibitors (ACEIs; e.g., captopril, ramipril)
  • angiotensin II receptor blockers (ARBs; e.g., irbesartan, losartan)
  • antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine, diphenhydramine)
  • antimalarials (e.g., chloroquine, hydroxychloroquine, mefloquine, quinine)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzepine, quetiapine, risperidone)
  • asunaprevir
  • atomoxetine
  • azelastine
  • barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
  • beta-agonists (asthma medications; e.g., salbutamol, salmeterol, formoterol)
  • bortezomib
  • brimonidine
  • buprenorphine
  • bupropion
  • calcium channel blockers (e.g., verapamil, diltiazem, nifedipine, amlodipine)
  • celecoxib
  • ceritinib
  • cholecalciferol
  • cimetidine
  • cinacalcet
  • clobazam
  • clotrimazole
  • cobicistat
  • cocaine
  • cyproterone
  • darifenacin
  • delavirdine
  • dextromethorphan
  • digoxin
  • diuretics (water pills; e.g., furosemide, hydrochlorothiazide)
  • dipyridamole
  • disopyramide
  • disulfiram
  • donepezil
  • doxorubicin
  • dronedarone
  • entacapone
  • epinephrine
  • ergot derivatives (e.g., bromocriptine, ergotamine, methylergonovine)
  • fentanyl
  • fingolimod
  • flecainide
  • floctafenine
  • galantamine
  • ginger
  • ginseng
  • grass pollen allergen extract
  • guanfacine
  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • imatinib
  • insulin
  • isoniazid
  • ketoconazole
  • lacosamide
  • lanreotide
  • levodopa
  • lidocaine
  • lomustine
  • methacholine
  • methadone
  • methimazole
  • methoxsalen
  • methylphenidate
  • metoclopramide
  • midodrine
  • mifepristone
  • milk thistle
  • mirabegron
  • moclobemide
  • nefazodone
  • nevirapine
  • nilotinib
  • nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
  • nonsteroidal anti-inflammatories (NSAIDs; e.g., ibuprofen, indomethacin, naproxen)
  • norepinephrine
  • octreotide
  • orphenadrine
  • other beta-blockers (e.g., atenolol, pindolol, propranolol)
  • oxybutynin
  • pasireotide
  • pazopanib
  • peginterferon alfa-2b
  • pentoxifylline
  • phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)
  • pilocarpine
  • pimozide
  • praziquantel
  • propafenone
  • proton pump inhibitors (e.g., lansoprazole, omeprazole, rabeprazole)
  • quinidine
  • quinine
  • ranitidine
  • regorafenib
  • rifabutin
  • rifampin
  • rituximab
  • rivastigmine
  • ropinirole
  • selective serotonin reuptake inhibitors (e.g., fluoxetine, paroxetine, sertraline)
  • serotonin antagonists (anti-emetic medications; e.g., dolasetron, granisetron, ondansetron)
  • serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
  • sodium phenylbutyrate
  • "statin" cholesterol medications (e.g., pravastatin, simvastatin)
  • sulfonylureas (e.g., gliclazide, glyburide, tolbutamide)
  • temsirolimus
  • terbinafine
  • theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
  • ticagrelor
  • ticlopidine
  • tizanidine
  • tofacitinib
  • tolcapone
  • tranylcypromine
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • yohimbine

If you are taking any medications containing this drug, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription) and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or illegal drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2018. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Mylan-Metoprolol

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