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How does this medication work? What will it do for me?
Metoclopramide belongs to the classes of medications called antiemetics and prokinetics. It is used to improve stomach emptying after surgery or other procedures. It can also be used to prevent nausea after operations and is useful in preventing the nausea and vomiting associated with cancer chemotherapy. It works by speeding up the rate at which the stomach empties and by blocking nausea triggers in the brain.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each square, white, flat tablet, debossed "P" on one side and "M 5" on the other side, contains 5 mg metoclopramide hydrochloride. Nonmedicinal ingredients: colloidal silicon dioxide, lactose, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.
Each white, round, biconvex tablet, debossed "P" on one side and "M" scored "10" on the other side, contains 10 mg metoclopramide hydrochloride. Nonmedicinal ingredients: colloidal silicon dioxide, lactose, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.
Each mL contains 1 mg metoclopramide hydrochloride. Nonmedicinal ingredients: citric acid, glycerin, methylparaben, orange natural & artificial flavour, propylene glycol, propylparaben, sodium citrate, sorbitol solution, and water.
How should I use this medication?
The recommended adult dose of metoclopramide for symptoms resulting from delayed stomach emptying ranges from 5 mg to 10 mg 3 or 4 times daily before meals. The recommended dose for children (aged 5 to 14 years) is 2.5 mg to 5 mg 3 times daily before meals. The injectable form of metoclopramide is most often used for the prevention of nausea and vomiting caused by chemotherapy. It is usually given by a health care professional in a hospital.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not use this medication if you are allergic to metoclopramide or any ingredients of the medication.
Metoclopramide should not be used in situations where faster passage of materials through the stomach might be dangerous (e.g., in cases of stomach bleeding or breaks in the stomach lining).
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- diarrhea (with high doses)
- restlessness or difficulty sleeping
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
July 20, 2011
Health Canada has issued new information concerning the use of metoclopramide. To read the full report, visit Health Canada's web site at www.hc-sc.gc.ca.
Drowsiness/reduced alertness : Metoclopramide may cause drowsiness and increase the drowsiness caused by alcohol and other drugs. Avoid driving and doing other potentially hazardous activities until you have determined the effect this medication has on you.
Medical conditions: If you have epilepsy, Parkinson's disease, or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking metoclopramide, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The total daily dose for children should not be higher than 0.5 mg per kilogram of body weight since with higher doses tremors and abnormal twitching movements can occur.
Seniors: Seniors appear to have a higher risk of side effects with long-term treatment of metoclopramide.
What other drugs could interact with this medication?
There may be an interaction between metoclopramide and any of the following:
- anticholinergic medications (e.g., scopolamine, tolterodine)
- antipsychotic medications (e.g., haloperidol, ziprasidone)
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- medications that cause drowsiness (e.g., sedatives such as lorazepam)
- narcotic medications (e.g., codeine, morphine)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material © 1996-2013 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
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