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How does this medication work? What will it do for me?
Sumatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called "triptans"). It is used to treat migraine headaches with or without aura (warning signs that occur prior to the onset of a migraine). The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Sumatriptan relieves migraine headaches by constricting these blood vessels.
Sumatriptan is not recommended for other types of headache or for headache prevention.
In most people, sumatriptan eliminates or reduces the symptoms of migraine, including headache, nausea, vomiting, and sensitivity to light and sound. Significant relief of migraine pain is usually experienced by about 10 to 15 minutes after using the injection, 15 minutes after using the nasal spray, and about 30 minutes after taking the oral tablets.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each white to off-white, round biconvex tablet, with a logo on one side and "SA" over "25" on the other, contains sumatriptan succinate 25 mg. Nonmedicinal ingredients: croscarmellose sodium, lactose, magnesium stearate, and microcrystalline cellulose.
Each white to off-white, triangular shaped biconvex tablet, with a logo on one side and "SA" over "50" on the other, contains sumatriptan succinate 50 mg. Nonmedicinal ingredients: croscarmellose sodium, lactose, magnesium stearate, and microcrystalline cellulose.
Each pink, triangular shaped biconvex tablet, with a logo on one side and "SA" over "100" on the other, contains sumatriptan succinate 100 mg. Nonmedicinal ingredients: croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, and red 30 iron oxide.
How should I use this medication?
The recommended adult dose of the tablets ranges from 25 mg to 100 mg. The most common dose is 50 mg.
If the headache returns, or if there is partial but not total relief, the dose may be repeated after 2 hours. If a dose has not helped your headache at all, do not take a second dose without first consulting a doctor. Not more than 200 mg should be taken during any 24-hour period.
The tablet should be swallowed whole with water, and not crushed, chewed, or split.
It is important to take this medication exactly as prescribed by your doctor.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.
This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Sumatriptan should not be used by anyone who:
- is allergic to sumatriptan or to any ingredients of the medication
- is taking monoamine oxidase (MAO) inhibitors (e.g., phenelzine, tranylcypromine) or has taken them within the past 2 weeks
- does not have a clear diagnosis of migraine
- has angina (chest pain), including Prinzmetal's angina (coronary vasospasm)
- has blood vessel disease (e.g., ischemic bowel disease, Raynaud's syndrome, stroke, transient ischemic attacks [TIAs])
- has certain types of migraine headaches (including hemiplegic, basilar, or ophthalmoplegic migraine)
- has had a heart attack
- has heart disease (e.g., heart valve disease, ischemic heart disease, abnormal heart rhythms, congenital heart disease)
- has high blood pressure that is severe or not under control
- has severely reduced liver function
- has taken another 5-hydroxytryptamine agonist (i.e., naratriptan, rizatriptan, zolmitriptan) in the previous 24 hours
- has taken ergotamine-containing or ergot-type medications (such as dihydroergotamine, ergotamine, or methysergide) in the previous 24 hours
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- burning, discharge, pain, or soreness in the nose (nasal spray)
- burning, pain, or redness at place of injection (injectable form only)
- change in taste sensation
- decreased saliva
- feelings of (in any part of the body):
- muscle aches
- nausea or vomiting
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- shaking, tremors, or uncontrolled movements
- skin rash, hives, itching, or bumps on skin
- slow, fast, or pounding heartbeat
- vision changes (usually temporary)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- convulsions (seizures)
- fast or irregular breathing
- heart attack (symptoms include pain, pressure, tightness, or heaviness in the chest, jaw, neck, or shoulder; sweating; or shortness of breath)
- irregular heartbeat
- loss of vision
- lower abdominal pain or severe rectal bleeding (blood in the stool or black, tarry stools)
- persistent purple discoloration of hands and feet
- severe allergic reaction (e.g., swelling of the face or throat, hives, difficulty breathing)
- stroke (e.g., sudden numbness or weakness, especially on one side of the body; sudden confusion or problems with speech; sudden vision problems in one or both eyes; sudden dizziness or loss of coordination; sudden severe headache, especially if it seems different from your usual headaches)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergy: People allergic to sulphonamides (sulfa medications) may experience an allergic reaction to sumatriptan. Reactions range from a skin allergy to a serious allergic reaction. People allergic to other medications in this class (5-hydroxytryptamine agonists such as rizatriptan and naratriptan) can also have an allergic reaction to sumatriptan. If you are allergic to any of these medications, you should not take sumatriptan unless advised to do so by your doctor.
Blood pressure: Sumatriptan may cause an increase in blood pressure. People with severe or uncontrolled high blood pressure should not take sumatriptan.
Drowsiness/reduced alertness: Drowsiness may occur as a result of taking this medication. Do not undertake potentially hazardous activities (e.g., driving or operating machinery) until you have determined that this medication does not affect you this way.
Heart disease: This medication may cause narrowing of the blood vessels that supply the heart. This can lead to chest pain, heart attacks, and other heart problems. For this reason, sumatriptan should not be used by people with heart or blood vessel disease. If you have certain risk factors for heart disease (e.g., high blood pressure, high cholesterol, smoking, obesity, diabetes, family history of coronary artery disease, menopause, men over 40 years of age), tell your doctor. If you experience symptoms of a heart attack (e.g., pain, pressure, tightness, or heaviness in the chest, jaw, neck, or shoulder; sweating; or shortness of breath), get immediate medical attention.
Injection: The injectable form of sumatriptan should never be taken intravenously (into a vein).
Kidney function: Sumatriptan is not recommended for use by people with reduced kidney function.
Liver function: A lower dose of sumatriptan may be needed for people with reduced liver function. However, sumatriptan is not recommended for use by people with severely reduced liver function.
Seizures: There have been rare reports of seizures experienced by people taking this medication. Most of these people had a previous history of epilepsy or medical conditions that increase the risk of seizures. People with a history of epilepsy or other conditions that increase their risk for seizure should discuss with their doctor how this medication may affect their medical condition and whether any special monitoring is needed.
Serotonin syndrome: People who use sumatriptan along with serotonin reuptake inhibitors (SSRIs; e.g., paroxetine, citalopram, fluoxetine) or serotonin norepinephrine reuptake inhibitors (SNRIs; e.g., venlafaxine) may experience serotonin syndrome. This syndrome is severe and can be life-threatening. If you are taking these medications, you should discuss with your doctor whether any special monitoring is needed. If you experience symptoms of serotonin syndrome (e.g., agitation, hallucinations, fast heartbeat, fever, increased reflexes, nausea, vomiting, diarrhea) after using sumatriptan, get immediate medical attention.
Stroke and bleeding around the brain: Rarely, this medication may cause cerebrovascular events such as stroke and bleeding around the brain. If you have had a previous stroke or are at risk for it, talk to your doctor about the use of this medication. If you experience signs and symptoms of a stroke (e.g., sudden numbness or weakness, especially on one side of the body; sudden confusion or problems with speech; sudden vision problems in one or both eyes; sudden dizziness or loss of coordination; sudden severe headache, especially if it seems different from your usual headaches), get immediate medical attention.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: Sumatriptan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children and adolescents: The safety and effectiveness of this medication have not been established for adolescents and children under 18 years of age.
Seniors: There is limited experience with the use of sumatriptan by people over 65 years of age. Its use by seniors is not recommended.
What other drugs could interact with this medication?
The following medications may affect the way that sumatriptan works or increase the risk of side effects:
- ergot-containing medications (e.g., dihydroergotamine, ergotamine, or methysergide), if taken at the same time or within the previous 24 hours
- MAO inhibitors (e.g., phenelzine, tranylcypromine), if taken at the same time or within 14 days of taking sumatriptan
- other 5-hydroxytryptamine agonists (e.g., rizatriptan, naratriptan, zolmitriptan), if taken at the same time or within the previous 24 hours
- SSRI-type antidepressants (e.g., paroxetine, fluoxetine, sertraline, fluvoxamine)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material © 1996-2013 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
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