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How does this medication work? What will it do for me?
Capecitabine belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the group of antineoplastics known as antimetabolites. Capecitabine fights cancer by killing and preventing the growth of cancer cells. Capecitabine is usually used alone or in combination with other medications to treat certain types of breast cancer and colorectal cancer.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each light peach-colored, biconvex, film-coated, oblong shaped tablet with "XELODA" engraved on one side and "150" on the reverse, contains capecitabine 150 mg. Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl methylcellulose, lactose anhydrous, magnesium stearate, microcrystalline cellulose, synthetic red iron oxide, synthetic yellow iron oxide, talc, and titanium dioxide.
Each peach-colored, biconvex, film-coated, oblong shaped tablet with "XELODA" engraved on one side and "500" on the reverse, contains capecitabine 500 mg. Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl methylcellulose, lactose anhydrous, magnesium stearate, microcrystalline cellulose, synthetic red iron oxide, synthetic yellow iron oxide, talc, and titanium dioxide.
How should I use this medication?
The recommended dose of capecitabine varies according to body size. Capecitabine is normally given in 2 equal doses twice a day for 2 weeks followed by a rest period of one week. This cycle is repeated until treatment is complete, as assessed by your doctor.
Capecitabine tablets should be swallowed with water within 30 minutes after the end of a meal.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you vomit shortly after taking capecitabine, contact your doctor for instruction on whether to take more medication or not. If you miss a dose of this medication, skip the missed dose and go back to your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
As well as interfering with the growth of cancer cells, capecitabine can interfere with some of your normal cells. This can cause a number of side effects such as mouth sores. Keep track of any side effects and report them to your doctor as suggested in the section, "What side effects are possible with this medication?"
Store this medication at room temperature, protect it from excessive heat and direct light, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Capecitabine should not be taken by anyone who:
- is allergic to capecitabine, 5-fluorouracil, or to any of the ingredients of the medication
- has dihydropyrimidine dehydrogenase (DPD) deficiency
- has severely reduced kidney function
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- loss of appetite
- mild diarrhea
- mild nausea or vomiting
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- abdominal or stomach pain
- diarrhea (more than 4 episodes during the day or any episodes at night)
- mild blistering, peeling, redness, or swelling of palms of hands or bottoms of feet
- mouth irritation, swelling, sores, or ulcer in mouth
- numbness, pain, tingling, or other unusual sensations in palms of hands or bottoms of feet
- severe nausea with loss of appetite
- severe vomiting
- signs of infection (e.g., fever, chills, sore throat, cough, painful urination)
- skin rash or itching
- swelling of fingers, feet, or lower legs
- unusual bruising or bleeding (e.g., bleeding gums, blood in the urine, nosebleeds, cuts that take longer to stop bleeding)
- unusual tiredness or weakness
Stop taking the medication and seek immediate medical attention if any of the following occur:
- abnormal heart rate
- chest pain
- signs of a severe allergic reaction (e.g., hives; difficulty breathing; swelling of the face, throat, or tongue)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
December 3, 2013
Health Canada has issued new restrictions concerning the use of Xeloda (capecitabine). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Diarrhea or dehydration: This medication frequently causes diarrhea. If you develop diarrhea that occurs more than 4 times a day or at all during the night, contact your doctor. Your doctor will monitor you closely for dehydration.
Hand and foot syndrome: This medication can cause hand and food syndrome (numbness, redness, tingling, burning, or pain in the hands and feet; blistering or peeling of the hands and feet). If you experience any of these symptoms, contact your doctor. If the symptoms are severe and interfere with your ability to walk or do other daily activities, stop taking this medication can contact your doctor immediately.
Heart disease: People with a history of heart disease may be more likely to experience side effects that affect the heart when taking this medication.
Kidney disease: People with reduced kidney function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. People with moderately to severely reduced kidney function will need lower doses of this medication.
Liver function: People with reduced liver function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: This medication may harm the baby if used during pregnancy. Women should avoid becoming pregnant while taking this medication. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if capecitabine passes into breast milk. Because of the risks associated with this medication, women should not breast-feed while taking capecitabine.
Children and adolescents: The safety and effectiveness of using this medication have not been established for children under 18 years of age.
What other drugs could interact with this medication?
There may be an interaction between capecitabine and any of the following:
- live vaccines (e.g., BCG, typhoid, yellow fever)
- other cancer-fighting medications
- some antacids
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material © 1996-2013 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
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