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How does this medication work? What will it do for me?
Clopidogrel belongs to the class of medications called platelet aggregation inhibitors or antiplatelets. Clopidogrel is used to help prevent heart attacks, strokes, and other circulation problems in people who have atherosclerosis (narrowed blood vessels caused by "hardening of the arteries") and have already experienced at least one atherothrombotic event such as heart attack, stroke, or diagnosed peripheral arterial disease (problems with blood flow in the arteries).It is also used with ASA (acetylsalicylic acid) by people with acute coronary syndrome or atrial fibrillation (a fast, irregular heartbeat).
Normally, platelets help the blood to clot when needed, such as after an injury. When arteries become narrowed by fat deposits (plaques), platelets often clump together in the vessels. Unstable plaques can rupture, leading to additional platelet clumping that can cause a larger blockage of the artery. This further narrows the arteries and increases the chances of heart attack, stroke, or other circulation problems. Clopidogrel reduces the chances of these events by preventing platelets from forming into clumps.
Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each round, pink, biconvex, film-coated tablet, engraved with "75" on one side and "1171" on the other side, contains clopidogrel bisulfate 97.9 mg which provides 75 mg of clopidogrel base. Nonmedicinal ingredients: hydrogenated castor oil, low substituted hydroxypropyl cellulose, mannitol, microcrystalline cellulose, and polyethylene glycol 6000; coating: carnauba wax, hypromellose, lactose, red iron oxide, titanium dioxide, and triacetin.
Each oblong, pink, film-coated tablet, engraved with “300” on one side and “1332” on the other side, contains clopidogrel bisulfate 391.5 mg which provides 300 mg of clopidogrel base. Nonmedicinal ingredients: hydrogenated castor oil, low substituted hydroxypropyl cellulose, mannitol, microcrystalline cellulose, and polyethylene glycol 6000; coating: carnauba wax, hypromellose, lactose, red iron oxide, titanium dioxide, and triacetin.
How should I use this medication?
The recommended adult dose of clopidogrel for most conditions is 75 mg once daily. When used by people with acute coronary syndromes, a 300 mg "loading dose" is initially prescribed. After this, treatment starts with 75 mg of clopidogrel once daily along with ASA once daily.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Clopidogrel may be taken with or without food.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose within 12 hours of your usual time, take it as soon as possible and continue with your regular schedule. If it is more than 12 hours, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not take clopidogrel if you:
- are allergic to clopidogrel or any ingredients of the medication
- have an active bleeding condition such as a stomach ulcer or a brain hemorrhage
- have significant liver disease or cholestatic jaundice
What side effects are possible with this medication?
Many medications can cause side-effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- joint or muscle pain
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- abdominal pain
- flu-like symptoms (sudden lack of energy, fever, cough, sore throat)
- signs of bleeding (e.g., nosebleeds, blood in urine, coughing blood, bleeding gums, unusual bruising or bleeding)
- signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- skin rash or itching
- symptoms of liver problems (i.e., yellowing of the skin or eyes, dark urine, light coloured stools, vomiting, nausea, abdominal pain)
- tingling sensation in the hands, arms, feet, or legs
Stop taking the medication and seek immediate medical attention if any of the following occur:
- chest pain
- signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up blood; vomiting blood or material that looks like coffee grounds)
- signs of a serious allergic reaction (i.e., swelling of face or throat, hives, or difficulty breathing)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
September 22, 2011
Health Canada has issued new information concerning the use of Plavix® (clopidogrel). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Bleeding problems: Clopidogrel increases the risk of bleeding. Using other medications (e.g., warfarin, NSAIDs) may further increase the risk of bleeding. If you have a history of bleeding disorders you should be monitored by your doctor while taking this medication.
If you have a history of bleeding disorders, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience signs of serious or excessive bleeding (e.g., bleeding from rectum, easy bruising, bloody urine, dark stools, persistent abdominal pain and vomiting), contact your doctor immediately.
Thrombotic thrombocytopenic purpura is a rare condition that may occur while taking clopidogrel and requires immediate medical attention. Signs include decreased number of blood cells, reduced kidney function, and fever. Seek immediate medical attention if you experience any of these symptoms while taking this medication.
Kidney function: If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Lactose intolerance: This medication contains lactose. If you have galactose intolerance (galactosemia, glucose-galactose malabsorption, or Lapp lactase deficiency) you should not take this medication.
Liver function: If you have reduced liver function or liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
People with severely reduced liver function should not take clopidogrel.
Proton pump inhibitors: Proton pump inhibitors (PPIs) are medications such as omeprazole and lansoprazole that are taken to treat stomach ulcers and severe heartburn. When clopidogrel is taken by people also taking a PPI, clopidogrel is less effective. If you are taking a medication in this class, discuss with your doctor whether you should continue to take it, or whether another medication may be more appropriate.
Stomach problems: Since clopidogrel can increase the risk of bleeding and slow down the time it takes to form a clot, it is important to remind your doctor if you have had stomach ulcers. Ask the doctor or your pharmacist to review your medications if they may cause stomach ulcers (e.g., NSAIDs such as ibuprofen, naproxen, and others).
Surgery: Your doctor may want to stop clopidogrel for a few days prior to any planned surgery to prevent any unnecessary bleeding, so it is important to tell any doctors that you are taking clopidogrel.
Pregnancy: The medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if clopidogrel passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding
Children: The safety and effectiveness of using this medication have not been established for children.
What other drugs could interact with this medication?
There may be an interaction between clopidogrel and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material © 1996-2013 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
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